The first book to focus on comprehensive systems biology as applied to drug discovery and development Drawing on real-life examples, Systems Biology in Drug Discovery and Development presents practical applications of systems biology to the multiple phases of drug discovery and development. This book explains how the integration of knowledge from multiple sources, and the models that best represent that integration, inform the drug research processes that are most relevant to the pharmaceutical and biotechnology industries. The first book to focus on comprehensive systems biology and its applications in drug discovery and development, it offers comprehensive and multidisciplinary coverage of all phases of discovery and design, including target identification and validation, lead identification and optimization, and clinical trial design and execution, as well as the complementary systems approaches that make these processes more efficient. It also provides models for applying systems biology to pharmacokinetics, pharmacodynamics, and candidate biomarker identification. Introducing and explaining key methods and technical approaches to the use of comprehensive systems biology on drug development, the book addresses the challenges currently facing the pharmaceutical industry. As a result, it is essential reading for pharmaceutical and biotech scientists, pharmacologists, computational modelers, bioinformaticians, and graduate students in systems biology, pharmaceutical science, and other related fields.
A thorough treatment of product and systems development in terms of value to all stakeholders Product and Systems Development compiles more than twenty years of research and practice from a value perspective, from vision and marketing to design, manufacturing, delivery, operations, and maintenance. It defines stakeholder value and identifies specific stakeholders in the product and system development process; covers best practices in development; and examines systems engineering, current industry views, and the life cycle of a value stream. Featuring appendices written by professionals in the field on topics such as Design Structure Matrices, Lean Enablers for systems engineering, and MDAO and simulations, this indispensable guide: Explains why stakeholders' values can hold the key to fulfillment or defeat of the developer's vision Emphasizes the succession of value-contributing practices and tools that form a framework for development success Integrates the technical, productivity, and customer/end-user elements in product and system development Uses more than 100 tables and figures to illustrate the above processes, as well as corollary elements of risk, failure analysis, and fault-tolerant design Includes numerous case studies and links to online material Product and Systems Development is an excellent coursebook for senior and graduate students in aerospace, mechanical, civil, electrical, and material engineering, as well as management science and engineering. It is also a useful reference for practicing engineers in a variety of technology-based industries.
Now covering both conventional and unmanned systems, this is a significant update of the definitive book on aircraft system design Design and Development of Aircraft Systems, Second Edition is for people who want to understand how industry develops the customer requirement into a fully integrated, tested, and qualified product that is safe to fly and fit for purpose. This edition has been updated to take into account the growth of unmanned air vehicles, together with updates to all chapters to bring them in line with current design practice and technologies as taught on courses at BAE Systems and Cranfield, Bristol and Loughborough universities in the UK. Design and Development of Aircraft Systems, Second Edition Provides a holistic view of aircraft system design describing the interaction between all of the subsystems such as fuel system, navigation, flight control etc. Covers all aspects of design including systems engineering, design drivers, systems architectures, systems integration, modelling of systems, practical considerations, & systems examples. Incorporates essential new material on Unmanned Aircraft Systems (UAS). Design and Development of Aircraft Systems, Second Edition has been written to be generic and not to describe any single process. It aims to complement other volumes in the Wiley Aerospace Series, in particular Aircraft Systems, Third Edition and Civil Avionics Systems by the same authors, and will inform readers of the work that is carried out by engineers in the aerospace industry to produce innovative and challenging – yet safe and reliable – systems and aircraft. Essential reading for Aerospace Engineers.
The use of computers has opened up remarkable opportunities for innovative design, improved productivity, and greater efficiency in the use of materials. Uniquely, this book focuses on the practical use of computers for clothing pattern design and product development. Readers are introduced to the various computer systems which are suitable for the industry, the principles and techniques of pattern design applied to computer systems are explained, and readers are shown how product data management can be used in clothing product development.
This text explores formation control of vehicle systems and introduces three representative systems: space systems, aerial systems and robotic systems Formation Control of Multiple Autonomous Vehicle Systems offers a review of the core concepts of dynamics and control and examines the dynamics and control aspects of formation control in order to study a wide spectrum of dynamic vehicle systems such as spacecraft, unmanned aerial vehicles and robots. The text puts the focus on formation control that enables and stabilizes formation configuration, as well as formation reconfiguration of these vehicle systems. The authors develop a uniform paradigm of describing vehicle systems’ dynamic behaviour that addresses both individual vehicle’s motion and overall group’s movement, as well as interactions between vehicles. The authors explain how the design of proper control techniques regulate the formation motion of these vehicles and the development of a system level decision-making strategy that increases the level of autonomy for the entire group of vehicles to carry out their missions. The text is filled with illustrative case studies in the domains of space, aerial and robotics. • Contains uniform coverage of «formation» dynamic systems development • Presents representative case studies in selected applications in the space, aerial and robotic systems domains • Introduces an experimental platform of using laboratory three-degree-of-freedom helicopters with step-by-step instructions as an example • Provides open source example models and simulation codes • Includes notes and further readings that offer details on relevant research topics, recent progress and further developments in the field Written for researchers and academics in robotics and unmanned systems looking at motion synchronization and formation problems, Formation Control of Multiple Autonomous Vehicle Systems is a vital resource that explores the motion synchronization and formation control of vehicle systems as represented by three representative systems: space systems, aerial systems and robotic systems.
MIVAR technologies of the development of intelligent systems and the creation of the active multi-subject online MIVAR encyclopaedia. The basic results of 25 years of development of the MIVAR technologies are described and compared with other methods of data storage and processing. A new project of creation of the active online MIVAR encyclopaedia is proposed.
Cost-effective strategies for designing novel drug delivery systems that target a broad range of disease conditions In vivo imaging has become an important tool for the development of new drug delivery systems, shedding new light on the pharmacokinetics, biodistribution, bioavailability, local concentration, and clearance of drug substances for the treatment of human disease, most notably cancer. Written by a team of international experts, this book examines the use of quantitative imaging techniques in designing and evaluating novel drug delivery systems and applications. Drug Delivery Applications of Noninvasive Imaging offers a full arsenal of tested and proven methods, practices and guidance, enabling readers to overcome the many challenges in creating successful new drug delivery systems. The book begins with an introduction to molecular imaging. Next, it covers: In vivo imaging techniques and quantitative analysis Imaging drugs and drug carriers at the site of action, including low-molecular weight radiopharmaceuticals, peptides and proteins, siRNA, cells, and nanoparticles Applications of imaging techniques in administration routes other than intravenous injection, such as pulmonary and oral delivery Translational research leading to clinical applications Imaging drug delivery in large animal models Clinical applications of imaging techniques to guide drug development and drug delivery Chapters are based on a thorough review of the current literature as well as the authors' firsthand experience working with imaging techniques for the development of novel drug delivery systems. Presenting state-of-the-technology applications of imaging in preclinical and clinical evaluation of drug delivery systems, Drug Delivery Applications of Noninvasive Imaging offers cost-effective strategies to pharmaceutical researchers and students for developing drug delivery systems that accurately target a broad range of disease conditions.
Bohdan W. Oppenheim has pulled together experience-based insights of experts across industry, government, and academia into a comprehensive sourcebook for lean systems engineering principles and practices. This book can educate those new to lean engineering, as well as provide new insights and enablers that best-in-class organizations will want to adopt. —Dr. Donna H. Rhodes, Principal Research Scientist, SEAri and LAI, Massachusetts Institute of Technology «Lean for Systems Engineering is targeted at the practitioner who is trying to make systems engineering more effective in her or his organization or program, yet its scholarly underpinnings make the text very suitable for teachers. Educators and trainers who wish to weave lean thinking into their systems engineering curriculum will find this an invaluable text.» —Earll M. Murman, Ford Professor of Engineering Emeritus, Massachusetts Institute of Technology "At last, a book that distills years of research and scholarly inquiry into a concise and coherent form for both the student and practitioner. This book will become the favored guide and 'must read' for any engineer and manager trying to establish and maintain lean practices and principles in their systems engineering/product development processes. —J. Robert Wirthlin, PhD, Lt. Col., USAF, Program Director of the Graduate Research and Development Management Program, Air Force Institute of Technology Visiting Faculty, U.S. Air Force Center for Systems Engineering «A vital contribution to linking lean practices to systems engineering. I will definitely use it as a reference for my course and writings on a value approach to product and system development.» —Dr. Stanley I. Weiss, Consulting Professor, Dept. of Aeronautics and Astronautics, Stanford University «Taking the opportunity to develop and refine the Lean Enablers for Systems Engineering provided clear direction for Lean Engineering Accelerated Planning at Rockwell Collins. The Lean Enablers form a solid basis for Lean Product Development. Following this checklist and methodology promotes Lean value and waste elimination—and commonsense best practices.» —Deborah A. Secor, Principal Project Manager and Lean Master, Rockwell Collins «Bo Oppenheim has been at the forefront of lean systems engineering for the better part of the last decade…An ardent advocate of lean systems engineering, the author has offered an honest appraisal of where lean systems engineering stands today. Practitioners interested in lean systems engineering will find the Lean Enablers especially useful.»– Azad M. Madni, PhD, Professor and Director, SAE Program, Viterbi School of Engineering; Professor, Keck School of Medicine, University of Southern California
Advanced research reference examining the closed and open quantum systems Control of Quantum Systems: Theory and Methods provides an insight into the modern approaches to control of quantum systems evolution, with a focus on both closed and open (dissipative) quantum systems. The topic is timely covering the newest research in the field, and presents and summarizes practical methods and addresses the more theoretical aspects of control, which are of high current interest, but which are not covered at this level in other text books. The quantum control theory and methods written in the book are the results of combination of macro-control theory and microscopic quantum system features. As the development of the nanotechnology progresses, the quantum control theory and methods proposed today are expected to be useful in real quantum systems within five years. The progress of the quantum control theory and methods will promote the progress and development of quantum information, quantum computing, and quantum communication. Equips readers with the potential theories and advanced methods to solve existing problems in quantum optics/information/computing, mesoscopic systems, spin systems, superconducting devices, nano-mechanical devices, precision metrology. Ideal for researchers, academics and engineers in quantum engineering, quantum computing, quantum information, quantum communication, quantum physics, and quantum chemistry, whose research interests are quantum systems control.
A comprehensive guide to the theory, methodology, and development for modeling systems of systems Modeling and Managing Interdependent Complex Systems of Systems examines the complexity of, and the risk to, emergent interconnected and interdependent complex systems of systems in the natural and the constructed environment, and in its critical infrastructures. For systems modelers, this book focuses on what constitutes complexity and how to understand, model and manage it.Previous modeling methods for complex systems of systems were aimed at developing theory and methodologies for uncoupling the interdependencies and interconnections that characterize them. In this book, the author extends the above by utilizing public- and private- sector case studies; identifies, explores, and exploits the core of interdependencies; and seeks to understand their essence via the states of the system, and their dominant contributions to the complexity of systems of systems. The book proposes a reevaluation of fundamental and practical systems engineering and risk analysis concepts on complex systems of systems developed over the past 40 years. This important resource: Updates and streamlines systems engineering theory, methodology, and practice as applied to complex systems of systems Introduces modeling methodology inspired by philosophical and conceptual thinking from the arts and sciences Models the complexity of emergent interdependent and interconnected complex systems of systems by analyzing their shared states, decisions, resources, and decisionmakers Written for systems engineers, industrial engineers, managers, planners, academics and other professionals in engineering systems and the environment,this text is the resource for understanding the fundamental principles of modeling and managing complex systems of systems, and the risk thereto.
As simulations become increasingly important in nearly all aspects of life, we're finding that combining existing systems is much more efficient than building newer, more complex replacements. Whether your interest is in business, the military, or entertainment or is even more general, Creating Computer Simulation Systems: An Introduction to the High Level Architecture will show you how to use the new standard for building and integrating modular simulation components and systems. The HLA, adopted by the U.S. Department of Defense, has been years in the making and recently has shot out ahead of its competitors to grab the attention of engineers and designers worldwide. The book/CD-ROM set contains an overview of the rationale and development of the HLA; a Windows-compatible implementation of the HLA Runtime Infrastructure (including test software); an extended, integrated tutorial that demonstrates its power and applicability to real-world problems; advanced topics and exercises; and well-thought-out programming examples in text and on disk. "The book's organization and design are top-notch - the chapters are nearly as modular as the systems they explore, though the meat of the book runs the reader through an extended set of problems focusing on the same model. Designed more as a guide than a reference, it is still well-indexed and a must for managers, technicians, programmers, and anyone else working on building simulations." Rob Lightner
A wide variety of flexible trading systems that combine sophisticated technical analysis with trading psychology theory Mechanical Trading Systems examines the development process for choosing and using mechanical trading systems in conjunction with trader psychology. This book discusses the advantages and disadvantages of mechanical trading systems; the dangers in system development and how to avoid them; the optimal methods for back-testing trading systems; position sizing and other risk quantification tools; and methods of improving rates of return on investments without significantly increasing risk. Most importantly, through a detailed examination of various types of unsuccessful trader personality traits (e.g., fearfulness, greed, and impatience), the book recommends different types of trading systems for a diverse array of trader types. Richard L. Weissman (Port Richey, FL) has seventeen years' experience as a trader and developer of trading systems. He currently provides independent consultation an d training services to traders and risk management professionals in the areas of technical analysis, risk management, and trader psychology.