Most books dedicated to the issues of bio-sensing are organized by the well-known scheme of a biosensor. In this book, the authors have deliberately decided to break away from the conventional way of treating biosensing research by uniquely addressing biomolecule immobilization methods on a solid surface, fluidics issues and biosensing-related transduction techniques, rather than focusing simply on the biosensor. The aim is to provide a contemporary snapshot of the biosensing landscape without neglecting the seminal references or products where needed, following the downscaling (from the micro- to the nanoscale) of biosensors and their respective best known applications. To conclude, a brief overview of the most popularized nanodevices applied to biology is given, before comparing biosensor criteria in terms of targeted applications.
Provides a broad range of information from basic principles to advanced applications of biosensors and nanomaterials in health care diagnostics This book utilizes a multidisciplinary approach to provide a wide range of information on biosensors and the impact of nanotechnology on the development of biosensors for health care. It offers a solid background on biosensors, recognition receptors, biomarkers, and disease diagnostics. An overview of biosensor-based health care applications is addressed. Nanomaterial applications in biosensors and diagnostics are included, covering the application of nanoparticles, magnetic nanomaterials, quantum dots, carbon nanotubes, graphene, and molecularly imprinted nanostructures. The topic of organ-specific health care systems utilizing biosensors is also incorporated to provide deep insight into the very recent advances in disease diagnostics. Biosensors and Nanotechnology: Applications in Health Care Diagnostics is comprised of 15 chapters that are presented in four sections and written by 33 researchers who are actively working in Germany, the United Kingdom, Italy, Turkey, Denmark, Finland, Romania, Malaysia and Brazil. It covers biomarkers in healthcare; microfluidics in medical diagnostics; SPR-based biosensor techniques; piezoelectric-based biosensor technologies; MEMS-based cell counting methods; lab-on-chip platforms; optical applications for cancer cases; and more. Discusses the latest technology and advances in the field of biosensors and their applications for healthcare diagnostics Particular focus on biosensors for cancer Summarizes research of the last 30 years, relating it to state-of-the-art technologies Biosensors and Nanotechnology: Applications in Health Care Diagnostics is an excellent book for researchers, scientists, regulators, consultants, and engineers in the field, as well as for graduate students studying the subject.
Technological needs for chemical, ionic and biological species detection are giving rise to continuous research and development in physico-chemistry and biology. The constant progress being made in the theoretical and technological aspects concerning studies and developments of chemical sensors, biosensors and biochips is presented in this book by different scientists and professors from different universities and constitutes an updating of the state of the art for chemical sensors, biosensors and biochips. This book places a large emphasis on interaction between chemical and biological species, in a gaseous or liquid state, and details mineral and biological materials acting as sensitive elements. The role of electrical, electrochemical, piezoelectric and optical transducers in detection mechanisms are presented through their developments and from a performance point-of-view. Micro-reactors, nanotechnologies and flexible substrates, are considered in relation to their role in neural networks. Contents 1. Chemical and Biological Recognition, Nicole Jaffrezic-Renault. 2. Adsorption Phenomena, René Lalauze. 3. Microcantilever Transduction, Isabelle Dufour. 4. Piezoelectric Transduction (QCM), Hubert Perrot. 5. Metal Oxide Gas Sensors, Christophe Pijolat. 6. Molecular Material-based Conductimetric Gas Sensors, Marcel Bouvet. 7. Responses and Electrical Properties of Gas Microsensors, Khalifa Aguir. 8. Gas Microsensor Technology, Philippe Menini. 9. Multisensors: Measurements and Behavior Models, Philippe Breuil. 10. Development of Microtechnologies for the Realization of Chemical, Biochemical and/or Biological Microsensors, Pierre Temple-Boyer. 11. Development of Micro-preconcentrators for the Detection of Gaseous Species at Trace Level, Jean-Paul Viricelle. 12. Microfluidics: Manipulation of Nanovolume Samples, Louis Renaud. 13. Electrochemical Biosensors, Chantal Gondran. 14. Fiber-optic Biosensors, Neso Sojic. 15. In Vivo Analyses with Electrochemical Microsensors, Stéphane Arbault. 16. Microbial Biosensors for Environmental Applications, Gérald Thouand and Marie José Durand. 17. Biofuel Cells, Serge Cosnier.
This book provides detailed reviews of a range of nanostructures used in the construction of biosensors as well as the applications of these biosensor nanotechnologies in the biological, chemical, and environmental monitoring fields Biological sensing is a fundamental tool for understanding living systems, but also finds practical application in medicine, drug discovery, process control, food safety, environmental monitoring, defense, and personal security. Moreover, a deeper understanding of the bio/electronic interface leads us towards new horizons in areas such as bionics, power generation, and computing. Advances in telecommunications, expert systems, and distributed diagnostics prompt us to question the current ways we deliver healthcare, while robust industrial sensors enable new paradigms in R&D and production. Despite these advances, there is a glaring absence of suitably robust and convenient sensors for body chemistries. This book examines some of the emerging technologies that are fueling scientific discovery and underpinning new products to enhance the length and quality of our lives. The 14 chapters written by leading experts cover such topics as: ZnO and graphene microelectrode applications in biosensing Assembly of polymers/metal nanoparticles Gold nanoparticle-based electrochemical biosensors Impedimetric DNA sensing employing nanomaterials Graphene and carbon nanotube-based biosensors Computational nanochemistry study of the BFPF green fluorescent protein chromophore Biosynthesis of metal nanoparticles Bioconjugated-nanoporous gold films in electrochemical biosensors The combination of molecular imprinting and nanotechnology Principles and properties of multiferroics and ceramics
An introduction to micro and nano replication processes and applications Micro/Nano Replication: Processes and Applications provides an overview of the fundamentals, processes, and applications involved in micro and nano replication in the manufacturing of product parts. A major field of nanotechnology, the study of micro/nano replication is sure to become one of increasing importance as the construction of completely new devices based on innovative concepts and crafted at the molecular level increases. Designed to help the reader understand and learn to work with the growing number of tools for molding plastic components, the book covers the key topics related to replication, including patterning technology, the modification of mold surface properties, and much more. In addition, it addresses the strengths and weaknesses of different molding processes. With a strong focus not only on how micro/nano replication works, but also the broader implications for the industry, the book is packed with examples of real world applications. These are drawn from a variety of fields, including information storage devices, optoelectronic elements, optical communication, and biosensors, in order to provide a complete view of the importance of micro and nano processes. A valuable introduction to a new but fast-growing field, Micro/Nano Replication is an essential resource for anyone looking to get a head start on understanding this emerging discipline.
New micro and nanopatterning technologies have been developed in the last years as less costly and more flexible alternatives to phtolithograpic processing. These technologies have not only impacted on recent developments in microelectronics, but also in emerging fields such as disposable biosensors, scaffolds for tissue engineering, non-biofouling coatings, high adherence devices, or photonic structures for the visible spectrum. This handbook presents the current processing methods suitable for the fabrication of micro- and nanostructured surfaces made out of polymeric materials. It covers the steps and materials involved, the resulting structures, and is rounded off by a part on applications. As a result, chemists, material scientists, and physicists gain a critical understanding of this topic at an early stage of its development.
Addressing a cutting-edge, multidisciplinary field, this book reviews nanomaterials and their biomedical applications. It covers regeneration, implants, adhesives, and biosensors and strategies for more efficient therapy, diagnosis, and drug delivery with the use of nanotechnology. • Addresses the increasing demand for nanomedicine in a cutting-edge, multidisciplinary field • Introduces concepts, strategies, and requirements of developing materials • Discusses hot topics in drug delivery, such as neural regeneration, cartilage regeneration, bone tissue regeneration, dental regeneration, biomedical imaging, tissue adhesives and biosensors • Includes a chapter about nanotoxicology to help readers further understand the biocompatability of nanomaterials
Bioelectrochemistry: Fundamentals, Experimental Techniques and Application, covers the fundamental aspects of the chemistry, physics and biology which underlie this subject area. It describes some of the different experimental techniques that can be used to study bioelectrochemical problems and it describes various applications of biolelectrochemisty including amperometric biosensors, immunoassays, electrochemistry of DNA, biofuel cells, whole cell biosensors, in vivo applications and bioelectrosynthesis. By bringing together these different aspects, this work provides a unique source of information in this area, approaching the subject from a cross-disciplinary viewpoint.
This book is the first of its kind to collectively address design-based and mechanical micro-manufacturing topics in one place. It focuses on design and materials selection, as well as the manufacturing of micro-products using mechanical-based micro-manufacturing process technologies. After addressing the fundamentals and non-metallic-based micro-manufacturing processes in the semiconductor industry, it goes on to address specific metallic-based micro-manufacturing processes, such as: micro-forming, micro-machining, micro-molding, micro-laser processing, micro-layered manufacturing, micro-joining, micro-assembly and materials handling, and microEDM and ECM. The book provides an in-depth understanding of materials behavior at micro-scales and under different micro-scale processing conditions, while also including a wide variety of emerging micro-scale manufacturing issues and examples.
Micro-Cutting: Fundamentals and Applications comprehensively covers the state of the art research and engineering practice in micro/nano cutting: an area which is becoming increasingly important, especially in modern micro-manufacturing, ultraprecision manufacturing and high value manufacturing. This book provides basic theory, design and analysis of micro-toolings and machines, modelling methods and techniques, and integrated approaches for micro-cutting. The fundamental characteristics, modelling, simulation and optimization of micro/nano cutting processes are emphasized with particular reference to the predictabilty, producibility, repeatability and productivity of manufacturing at micro and nano scales. The fundamentals of micro/nano cutting are applied to a variety of machining processes including diamond turning, micromilling, micro/nano grinding/polishing, ultraprecision machining, and the design and implementation of micro/nano cutting process chains and micromachining systems. Key features • Contains contributions from leading global experts • Covers the fundamental theory of micro-cutting • Presents applications in a variety of machining processes • Includes examples of how to implement and apply micro-cutting for precision and micro-manufacturing Micro-Cutting: Fundamentals and Applications is an ideal reference for manufacturing engineers, production supervisors, tooling engineers, planning and application engineers, as well as machine tool designers. It is also a suitable textbook for postgraduate students in the areas of micro-manufacturing, micro-engineering and advanced manufacturing methods.
This book will present the theoretical and technological elements of nanosystems. Among the different topics discussed, the authors include the electromechanical properties of NEMS, the scaling effects that give these their interesting properties for different applications and the current manufacturing processes. The authors aim to provide useful tools for future readers and will provide an accurate picture of current and future research in the field.
This book introduces the principles and concepts of chemical and biochemical sensors for analyzing medical as well as biological samples. For applications like analyzing or monitoring gastric juice or blood plasma, the potential of sensors is exceptionally large. Focussed on these applications, the interpretation of analytical results is explained. Specific advantages are compared to other analytical techniques. Numerous tables with data provide useful information not easily found elsewhere and make a handy source of reference. Ursula E. Spichiger-Keller is head of the Center for Chemical Sensors/Biosensors and Bioanalytical Chemistry at the Swiss Federal Institute of Technology (ETH) in Zurich.
This book covers the recent advances in the development of bioelectronics systems and their potential application in future biomedical applications starting from system design to signal processing for physiological monitoring, to in situ biosensing. Advanced Bioelectronics Materialshas contributions from distinguished international scholars whose backgrounds mirror the multidisciplinary readership ranging from the biomedical sciences, biosensors and engineering communities with diverse backgrounds, interests and proficiency in academia and industry. The readers will benefit from the widespread coverage of the current literature, state-of-the-art overview of all facets of advanced bioelectronics materials ranging from real time monitoring, in situ diagnostics, in vivo imaging, image-guided therapeutics, biosensors, and translational biomedical devices and personalized monitoring.
Key features include: Self-assessment questions and exercises Chapters start with essential principles, then go on to address more advanced topics More than 1300 references to direct the reader to key literature and further reading Highly illustrated with 450 figures, including chemical structures and reactions, functioning principles, constructive details and response characteristics Chemical sensors are self-contained analytical devices that provide real-time information on chemical composition. A chemical sensor integrates two distinct functions: recognition and transduction. Such devices are widely used for a variety of applications, including clinical analysis, environment monitoring and monitoring of industrial processes. This text provides an up-to-date survey of chemical sensor science and technology, with a good balance between classical aspects and contemporary trends. Topics covered include: Structure and properties of recognition materials and reagents, including synthetic, biological and biomimetic materials, microorganisms and whole-cells Physicochemical basis of various transduction methods (electrical, thermal, electrochemical, optical, mechanical and acoustic wave-based) Auxiliary materials used e.g. synthetic and natural polymers, inorganic materials, semiconductors, carbon and metallic materials properties and applications of advanced materials (particularly nanomaterials) in the production of chemical sensors and biosensors Advanced manufacturing methods Sensors obtained by combining particular transduction and recognition methods Mathematical modeling of chemical sensor processes Suitable as a textbook for graduate and final year undergraduate students, and also for researchers in chemistry, biology, physics, physiology, pharmacology and electronic engineering, this bookis valuable to anyone interested in the field of chemical sensors and biosensors.
The functional materials with the most promising outlook have the ability to precisely adjust the biological phenomenon in a controlled mode. Engineering of advanced bio- materials has found striking applications in used for biomedical and diagnostic device applications, such as cell separation, stem-cell, drug delivery, hyperthermia, automated DNA extraction, gene targeting, resonance imaging, biosensors, tissue engineering and organ regeneration.