Summarizes research encompassing all of the aspects required to understand, fabricate and integrate enzymatic fuel cells Contributions span the fields of bio-electrochemistry and biological fuel cell research Teaches the reader to optimize fuel cell performance to achieve long-term operation and realize commercial applicability Introduces the reader to the scientific aspects of bioelectrochemistry including electrical wiring of enzymes and charge transfer in enzyme fuel cell electrodes Covers unique engineering problems of enzyme fuel cells such as design and optimization
Enzyme biocatalysis is a fast-growing area in process biotechnology that has expanded from the traditional fields of foods, detergents, and leather applications to more sophisticated uses in the pharmaceutical and fine-chemicals sectors and environmental management. Conventional applications of industrial enzymes are expected to grow, with major opportunities in the detergent and animal feed sectors, and new uses in biofuel production and human and animal therapy. In order to design more efficient enzyme reactors and evaluate performance properly, sound mathematical expressions must be developed which consider enzyme kinetics, material balances, and eventual mass transfer limitations. With a focus on problem solving, each chapter provides abridged coverage of the subject, followed by a number of solved problems illustrating resolution procedures and the main concepts underlying them, plus supplementary questions and answers. Based on more than 50 years of teaching experience, Problem Solving in Enzyme Biocatalysis is a unique reference for students of chemical and biochemical engineering, as well as biochemists and chemists dealing with bioprocesses. Contains: Enzyme properties and applications; enzyme kinetics; enzyme reactor design and operation 146 worked problems and solutions in enzyme biocatalysis.
Lignocellulosic Biomass Production and Industrial Applications describes the utilization of lignocellulosic biomass for various applications. Although there have been numerous reports on lignocellulosic biomass for biofuel application, there have been very few other applications reported for lignocellulosic biomass-based chemicals and polymers. Therefore, this book covers all of the possible lignocellulosic biomass applications. Besides describing the different types of biofuel production, such as bioethanol, biobutanol, biodiesel and biogas from lignocellulosic biomass, it also presents various other lignocellulosic biomass biorefinery applications for the production of chemicals, polymers, paper and bioplastics. In addition, there are chapters on valorization of lignocellulosic materials, alkali treatment to improve the physical, mechanical and chemical properties of lignocellulosic natural fibers, and a discussion of the major benefits, limitations and future prospects of the use of lignocellulosic biomass.
Provides a broad range of information from basic principles to advanced applications of biosensors and nanomaterials in health care diagnostics This book utilizes a multidisciplinary approach to provide a wide range of information on biosensors and the impact of nanotechnology on the development of biosensors for health care. It offers a solid background on biosensors, recognition receptors, biomarkers, and disease diagnostics. An overview of biosensor-based health care applications is addressed. Nanomaterial applications in biosensors and diagnostics are included, covering the application of nanoparticles, magnetic nanomaterials, quantum dots, carbon nanotubes, graphene, and molecularly imprinted nanostructures. The topic of organ-specific health care systems utilizing biosensors is also incorporated to provide deep insight into the very recent advances in disease diagnostics. Biosensors and Nanotechnology: Applications in Health Care Diagnostics is comprised of 15 chapters that are presented in four sections and written by 33 researchers who are actively working in Germany, the United Kingdom, Italy, Turkey, Denmark, Finland, Romania, Malaysia and Brazil. It covers biomarkers in healthcare; microfluidics in medical diagnostics; SPR-based biosensor techniques; piezoelectric-based biosensor technologies; MEMS-based cell counting methods; lab-on-chip platforms; optical applications for cancer cases; and more. Discusses the latest technology and advances in the field of biosensors and their applications for healthcare diagnostics Particular focus on biosensors for cancer Summarizes research of the last 30 years, relating it to state-of-the-art technologies Biosensors and Nanotechnology: Applications in Health Care Diagnostics is an excellent book for researchers, scientists, regulators, consultants, and engineers in the field, as well as for graduate students studying the subject.
Sets the stage for advances in drug discovery using the latest enzyme technology Reviewing new and emerging applications of enzyme technology in drug discovery, this book highlights some of the most promising areas of pharmaceutical and biotechnology research. It covers enzyme assay technology, utilization of enzymology for prodrug design, and the application of enzymes as therapeutic agents. Expert reviews highlight how our latest understanding of enzymology is used to develop new practical applications in drug discovery and design. Filled with case studies, Enzyme Technologies: Pluripotent Players in Discovering Therapeutic Agents enables readers to better understand the diverse functions of enzymes and master specific applications in drug discovery research. In addition to small molecule drug discovery, the book explores new developments in enzymes as therapeutic agents for genetic disorders. Section A, Enzymes – Essential Workhorses in Pharmaceutical Research, offers support in selecting the best enzyme targets for drug discovery, designing enzyme inhibitors for therapeutic agents, and evaluating selective enzyme inhibitors. Section B, Enzymes – Indispensable Tools for Improving Druggability, sets forth the principles alongside real-world examples of exploiting specific properties of enzymes to design successful prodrugs. Section C, Enzymes – Powerful Weapons for Correcting Nature's Errors, provides new insights on applying enzymes as therapeutic agents or diagnostic tools to treat genetic disorders. Chapters are contributed by leading experts from around the world. Their contributions are based on a thorough review of the current literature as well as their own research. Reviewing our latest understanding of the nature of enzymes and their role in drug discovery, this book is recommended for researchers in pharmaceuticals and biotechnology as well as for researchers in enzymology, biochemistry, molecular biology, and medicinal chemistry.
Bioelectrochemistry: Fundamentals, Experimental Techniques and Application, covers the fundamental aspects of the chemistry, physics and biology which underlie this subject area. It describes some of the different experimental techniques that can be used to study bioelectrochemical problems and it describes various applications of biolelectrochemisty including amperometric biosensors, immunoassays, electrochemistry of DNA, biofuel cells, whole cell biosensors, in vivo applications and bioelectrosynthesis. By bringing together these different aspects, this work provides a unique source of information in this area, approaching the subject from a cross-disciplinary viewpoint.
This book covers the recent advances in electrode materials and their novel applications at the cross-section of advanced materials. The book is divided into two sections: State-of-the-art electrode materials; and engineering of applied electrode materials. The chapters deal with electrocatalysis for energy conversion in view of bionanotechnology; surfactant-free materials and polyoxometalates through the concepts of biosensors to renewable energy applications; mesoporous carbon, diamond, conducting polymers and tungsten oxide/conducting polymer-based electrodes and hybrid systems. Numerous approaches are reviewed for lithium batteries, fuel cells, the design and construction of anode for microbial fuel cells including phosphate polyanion electrodes, electrocatalytic materials, fuel cell reactions, conducting polymer based hybrid nanocomposites and advanced nanomaterials.
The first book to provdie a comprehensive look at bioenergetics, the energy flow in living systems, by studying ion exchange and electron transfer processes in biological membranes and artificial bio-films, and how these processes contribute to developing modern biosensor and ion-sensor technology, as well as biofuel cells. The book: Discusses the ion fluxes and electron transfer processes in biological membranes and artificial bio-films Provides an in-depth description of the processes at the interface between the membrane/film and substrate electrode Is the first of its kind to provide a comprehensive look at how these processes are understood in biology of living cells Addresses how these processes contribute to developing modern biosensor and ion-sensor technology, as well as biofuel cells
This second edition of a bestselling textbook offers an instructive and comprehensive overview of our current knowledge of biocatalysis and enzyme technology. The book now contains about 40% more printed content. Three chapters are completely new, while the others have been thoroughly updated, and a section with problems and solutions as well as new case studies have been added. Following an introduction to the history of enzyme applications, the text goes on to cover in depth enzyme mechanisms and kinetics, production, recovery, characterization and design by protein engineering. The authors treat a broad range of applications of soluble and immobilized biocatalysts, including wholecell systems, the use of non-aqueous reaction systems, applications in organic synthesis, bioreactor design and reaction engineering. Methods to estimate the sustainability, important internet resources and their evaluation, and legislation concerning the use of biocatalysts are also covered.
Biofuel Crop Sustainability brings together the basic principles of agricultural sustainability and special stipulations for biofuels, from the economic and ecological opportunities and challenges of sustainable biofuel crop production to the unique characteristics of particular crops which make them ideal for biofuel applications. This book will be a valuable resource for researchers and professionals involved in biofuels development and production as well as agriculture industry personnel. Chapters focus the broad principles of resource management for ecological, environmental and societal welfare, the sustainability issues pertaining to several broad categories of biofuel crops , as well as the economics and profitability of biofuels on both a local and international scale. Coverage includes topics such as utilizing waste water for field crop irrigation and algae production, reliability of feedstock supply, marginal lands, and identifying crops with traits of significance for survival and growth on low fertility soils. The development of production practices with low external inputs of fertilizer, irrigation, and pesticides is also covered. Biofuel Crop Sustainability will be a valuable, up-to-date reference for all those involved in the rapidly expanding biofuels industry and sustainable agriculture research fields.
Stem Cells: A Short Course is a comprehensive text for students delving into the rapidly evolving discipline of stem cell research. Comprised of eight chapters, the text addresses all of the major facets and disciplines related to stem cell biology and research. A brief history of stem cell research serves as an introduction, followed by coverage of stem cell fundamentals; chapters then explore embryonic and fetal amniotic stem cells, adult stem cells, nuclear reprogramming, and cancer stem cells. The book concludes with chapters on stem cell applications, including the role of stem cells in drug discovery and therapeutic applications in spinal cord injury, brain damage, neurological and autoimmune disorders, among others. Written by a leader in the field, Stem Cells: A Short Course appeals to both students and instructors alike, appealing to academic enthusiasm for stem cell research and applications.
Rapid-Equilibrium Enzyme Kinetics helps readers emphasize the estimation of kinetic parameters with the minimum number of velocity measurements, thereby reducing the amount of laboratory work necessary, and allowing more time for the consideration of complicated mechanisms. The book systematically progresses through six levels of understanding the enzyme-catalyzed reaction, and includes a CD-ROM so that the reader may use the programs in the book to input their own experimental data.
Brings together functional and structural informationrelevant to the design of drugs targeting zinc enzymes The second most abundant transition element in living organisms, zinc spans all areas of metabolism, with zinc-containing proteins offering both established and potential drug targets. Drug Design of Zinc-Enzyme Inhibitors brings together functional and structural information relevant to these zinc-containing targets. With up-to-date overviews of the latest developments field, this unique and comprehensive text enables readers to understand zinc enzymes and evaluate them in a drug design context. With contributions from the leaders of today's research, Drug Design of Zinc-Enzyme Inhibitors covers such key topics as: Major drug targets like carbonic anhydrases, matrix metalloproteinases, bacterial proteases, angiotensin-converting enzyme, histone deacetylase, and APOBEC3G Roles of recently discovered zinc-containing isozymes in cancer, obesity, epilepsy, pain management, malaria, and other conditions Cross reactivity of zinc-enzyme inhibitors and activators The extensive use of X-ray crystallography and QSAR studies for understanding zinc-containing proteins Clinical applications An essential resource for the discovery and development of new drug molecules, Drug Design of Zinc-Enzyme Inhibitors gives researchers, professionals, students, and academics the foundation to understand and work with zinc enzyme inhibitors and activators.
The book gives an overview on the current development status of synthetic diamond films and their applications. Its initial part is devoted to discuss the different types of conductive diamond electrodes that have been synthesized, their preparation methods, and their chemical properties and characterization. The electrochemical properties of diamond films in different scientific areas, with special attention in electroanalysis, are further described. Different strategies to modify these electrodes are also discussed as important technologies with ability to change their electrochemical characteristics for a more specific electroanalytical use. The second part of the book deals with practical applications of diamond electrodes to the industry, organic electrosynthesis, electrochemical energy technology, and biotechnology. Special emphasis is made on the properties of these materials for the production of strong oxidizing species allowing the fast mineralization of organics and their use for water disinfection and decontamination. Recent biotechnological development on biosensors, microelectrodes, and nanostructured electrodes, as well as on neurochemistry, is also presented. The book will be written by a large number of internationally recognized experts and comprises 24 chapters describing the characteristics and theoretical fundaments of the different electrochemical uses and applications of synthetic diamond films.