Micro-Cutting: Fundamentals and Applications comprehensively covers the state of the art research and engineering practice in micro/nano cutting: an area which is becoming increasingly important, especially in modern micro-manufacturing, ultraprecision manufacturing and high value manufacturing. This book provides basic theory, design and analysis of micro-toolings and machines, modelling methods and techniques, and integrated approaches for micro-cutting. The fundamental characteristics, modelling, simulation and optimization of micro/nano cutting processes are emphasized with particular reference to the predictabilty, producibility, repeatability and productivity of manufacturing at micro and nano scales. The fundamentals of micro/nano cutting are applied to a variety of machining processes including diamond turning, micromilling, micro/nano grinding/polishing, ultraprecision machining, and the design and implementation of micro/nano cutting process chains and micromachining systems. Key features • Contains contributions from leading global experts • Covers the fundamental theory of micro-cutting • Presents applications in a variety of machining processes • Includes examples of how to implement and apply micro-cutting for precision and micro-manufacturing Micro-Cutting: Fundamentals and Applications is an ideal reference for manufacturing engineers, production supervisors, tooling engineers, planning and application engineers, as well as machine tool designers. It is also a suitable textbook for postgraduate students in the areas of micro-manufacturing, micro-engineering and advanced manufacturing methods.
According to the NACFAM (National Council for Advanced Manufacturing USA) Sustainable Manufacturing is defined as the creation of manufactured products that use processes that are non-polluting, conserve energy and natural resources, and are economically sound and safe for employees, communities, and consumers. The book covers Sustainable Manufacturing techniques such as materials and manufacturing for renewable energies; clean manufacturing technology; ecological manufacturing; energy-efficient manufacturing; remanufacturing; recycling of materials; environmentally conscious design and manufacturing processes; sustainable advanced manufacturing systems; manufacturability in sustainable product design; education and training for sustainable manufacturing.
Most books dedicated to the issues of bio-sensing are organized by the well-known scheme of a biosensor. In this book, the authors have deliberately decided to break away from the conventional way of treating biosensing research by uniquely addressing biomolecule immobilization methods on a solid surface, fluidics issues and biosensing-related transduction techniques, rather than focusing simply on the biosensor. The aim is to provide a contemporary snapshot of the biosensing landscape without neglecting the seminal references or products where needed, following the downscaling (from the micro- to the nanoscale) of biosensors and their respective best known applications. To conclude, a brief overview of the most popularized nanodevices applied to biology is given, before comparing biosensor criteria in terms of targeted applications.
The book addresses the basics, applications, and manufacturing of plasmid biopharmaceuticals. The survey of the most relevant characteristics of plasmids provides the basics for designing plasmid products (applications) and processes (manufacturing). Key features that the authors include in the book are: i) consistency and clear line of direction, ii) an extensive use of cross-referencing between the individual chapters, iii) a rational integration of chapters, iv) appellative figures, tables and schemes, and v) an updated, but selected choice of references, with a focus on key papers.
Written by the most prominent experts and pioneers in the field, this ready reference combines fundamental research, recent breakthroughs and real-life applications in one well-organized treatise. As such, both newcomers and established researchers will find here a wide range of current methods for producing and characterizing carbon nanotubes using imaging as well as spectroscopic techniques. One major part of this thorough overview is devoted to the controlled chemical functionalization of carbon nanotubes, covering intriguing applications in photovoltaics, organic electronics and materials design. The latest research on novel carbon-derived structures, such as graphene, nanoonions and carbon pea pods, round off the book.
The development and application of multivariate statistical techniques in process monitoring has gained substantial interest over the past two decades in academia and industry alike. Initially developed for monitoring and fault diagnosis in complex systems, such techniques have been refined and applied in various engineering areas, for example mechanical and manufacturing, chemical, electrical and electronic, and power engineering. The recipe for the tremendous interest in multivariate statistical techniques lies in its simplicity and adaptability for developing monitoring applications. In contrast, competitive model, signal or knowledge based techniques showed their potential only whenever cost-benefit economics have justified the required effort in developing applications. Statistical Monitoring of Complex Multivariate Processes presents recent advances in statistics based process monitoring, explaining how these processes can now be used in areas such as mechanical and manufacturing engineering for example, in addition to the traditional chemical industry. This book: Contains a detailed theoretical background of the component technology. Brings together a large body of work to address the field’s drawbacks, and develops methods for their improvement. Details cross-disciplinary utilization, exemplified by examples in chemical, mechanical and manufacturing engineering. Presents real life industrial applications, outlining deficiencies in the methodology and how to address them. Includes numerous examples, tutorial questions and homework assignments in the form of individual and team-based projects, to enhance the learning experience. Features a supplementary website including Matlab algorithms and data sets. This book provides a timely reference text to the rapidly evolving area of multivariate statistical analysis for academics, advanced level students, and practitioners alike.
An informative and comprehensive book on the applications and techniques of dried blood spot sampling Dried blood spot (DBS) sampling involves the collection of a small volume of blood, via a simple prick or other means, from a study subject onto a cellulose or polymer paper card, which is followed by drying and transfer to the laboratory for analysis. For many years, this method of blood sample collection has been extensively utilized in some important areas of human healthcare (for example, newborn screening for inherited metabolic disorders and HIV-related epidemiological studies). Because of its advantages over conventional blood, plasma, or serum sample collection, DBS sampling has been valued by the pharmaceutical industry in drug research and development. Dried Blood Spots: Applications and Techniques features contributions from an international team of leading scientists in the field. Their contributions present a unique resource on the history, principles, procedures, methodologies, applications, and emerging technologies related to DBS. Presented in three parts, the book thoroughly examines: Applications of DBS sampling and associated procedures and methodologies in various human healthcare studies Applications and perspectives of DBS sampling in drug research and development, and therapeutic drug monitoring New technologies and emerging applications related to DBS sampling and analysis Dried Blood Spots: Applications and Techniques is a valuable working guide for researchers, professionals, and students in healthcare, medical science, diagnostics, clinical chemistry, and pharmaceuticals, etc.
This book focuses on new techniques, analysis, applications and future trends of microstrip and printed antenna technologies, with particular emphasis to recent advances from the last decade Attention is given to fundamental concepts and techniques, their practical applications and the future scope of developments. Several topics, essayed as individual chapters include reconfigurable antenna, ultra-wideband (UWB) antenna, reflectarrays, antennas for RFID systems and also those for body area networks. Also included are antennas using metamaterials and defected ground structures (DGSs). Essential aspects including advanced design, analysis and optimization techniques based on the recent developments have also been addressed. Key Features: Addresses emerging hot topics of research and applications in microstrip and printed antennas Considers the fundamental concepts, techniques, applications and future scope of such technologies Discusses modern applications such as wireless base station to mobile handset, satellite earth station to airborne communication systems, radio frequency identification (RFID) to body area networks, etc. Contributions from highly regarded experts and pioneers from the US, Europe and Asia This book provides a reference for R&D researchers, professors, practicing engineers, and scientists working in these fields. Graduate students studying/working on related subjects will find this book as a comprehensive literature for understanding the present and future trends in microstrip and printed antennas.
Approaching the topic of digital holography from the practical perspective of industrial inspection, Digital Holography for MEMS and Microsystem Metrology describes the process of digital holography and its growing applications for MEMS characterization, residual stress measurement, design and evaluation, and device testing and inspection. Asundi also provides a thorough theoretical grounding that enables the reader to understand basic concepts and thus identify areas where this technique can be adopted. This combination of both practical and theoretical approach will ensure the book's relevance and appeal to both researchers and engineers keen to evaluate the potential of digital holography for integration into their existing machines and processes. Addresses particle characterization where digital holography has proven capability for dynamic measurement of particles in 3D for sizing and shape characterization, with applications in microfluidics as well as crystallization and aerosol detection studies. Discusses digital reflection holography, digital transmission holography, digital in-line holography, and digital holographic tomography and applications. Covers other applications including micro-optical and diffractive optical systems and the testing of these components, and bio-imaging.
Describing advanced detectors and their visualization and investigation techniques, this book presents the major applications in nuclear and high-energy physics, astrophysics, medicine and radiation measurements.
Like its predecessor this book is devoted to the materials, manufacturing and applications aspects of organic thin-film transistors. Once again authored by the most renowned experts from this fascinating and fast-moving area of research, it offers a joint perspective both broad and in-depth on the latest developments in the areas of materials chemistry, transport physics, materials characterization, manufacturing technology, and circuit integration of organic transistors. With its many figures and detailed index, this book once again also serves as a ready reference.
Generally a laser (light amplification by stimulated emission of radiation) is defined as “a device which uses a quantum mechanical effect, stimulated emission, to generate a coherent beam of light from a lasing medium of controlled purity, size, and shape”. Laser material processing represents a great number of methods, which are rapidly growing in current and different industrial applications as new alternatives to traditional manufacturing processes. Nowadays, the use of lasers in manufacturing is an emerging area with a wide variety of applications, for example, in electronics, molds and dies, and biomedical applications. The purpose of this book is to present a collection of examples illustrating the state of the art and research developments to lasers in manufacturing, covering laser rapid manufacturing, lasers in metal forming applications, laser forming of metal foams, mathematical modeling of laser drilling, thermal stress analysis, modeling and simulation of laser welding, and the use of lasers in surface engineering. This book can be used as a research book for a final undergraduate engineering course or as a subject on lasers in manufacturing at the postgraduate level. Also, this book can serve as a useful reference for academics, laser researchers, mechanical, manufacturing, materials or physics engineers, or professionals in any related modern manufacturing technology. Contents 1. Laser Rapid Manufacturing: Technology, Applications, Modeling and Future Prospects, Christ P. Paul, Pankaj Bhargava, Atul Kumar, Ayukt K. Pathak and Lalit M. Kukreja. 2. Lasers in Metal Forming Applications, Stephen A. Akinlabi, Mukul Shukla, Esther T. Akinlabi and Tshilidzi Marwala. 3. Laser Forming of Metal Foams, Fabrizio Quadrini, Denise Bellisario, Erica A. Squeo and Loredana Santo. 4. Mathematical Modeling of Laser Drilling, Maturose Suchatawat and Mohammad Sheikh. 5. Laser Cutting a Small Diameter Hole: Thermal Stress Analysis, Bekir S. Yilbas, Syed S. Akhtar and Omer Keles. 6. Modeling and Simulation of Laser Welding, Karuppudaiyar R. Balasabramanian, Krishnasamy Sankaranarayanasamy and Gangusami N. Buvanashekaran. 7. Lasers in Surface Engineering, Alberto H. Garrido, Rubén González, Modesto Cadenas, Chin-Pei Wang and Farshid Sadeghi.
Closes the gap between hardcore-theoretical and purely experimental RF-MEMS books. The book covers, from a practical viewpoint, the most critical steps that have to be taken in order to develop novel RF-MEMS device concepts. Prototypical RF-MEMS devices, both including lumped components and complex networks, are presented at the beginning of the book as reference examples, and these are then discussed from different perspectives with regard to design, simulation, packaging, testing, and post-fabrication modeling. Theoretical concepts are introduced when necessary to complement the practical hints given for all RF-MEMS development stages. Provides researchers and engineers with invaluable practical hints on how to develop novel RF-MEMS device concepts Covers all critical steps, dealing with design, simulation, optimization, characterization and fabrication of MEMS for radio-frequency applications Addresses frequently disregarded issues, explicitly treating the hard to predict interplay between the three-dimensional device structure and its electromagnetic functionality Bridges theory and experiment, fundamental concepts are introduced with the application in mind, and simulation results are validated against experimental results Appeals to the practice-oriented R&D reader: design and simulation examples are based on widely known software packages such as ANSYS and the hardware description language Verilog.
Cost-effective strategies for designing novel drug delivery systems that target a broad range of disease conditions In vivo imaging has become an important tool for the development of new drug delivery systems, shedding new light on the pharmacokinetics, biodistribution, bioavailability, local concentration, and clearance of drug substances for the treatment of human disease, most notably cancer. Written by a team of international experts, this book examines the use of quantitative imaging techniques in designing and evaluating novel drug delivery systems and applications. Drug Delivery Applications of Noninvasive Imaging offers a full arsenal of tested and proven methods, practices and guidance, enabling readers to overcome the many challenges in creating successful new drug delivery systems. The book begins with an introduction to molecular imaging. Next, it covers: In vivo imaging techniques and quantitative analysis Imaging drugs and drug carriers at the site of action, including low-molecular weight radiopharmaceuticals, peptides and proteins, siRNA, cells, and nanoparticles Applications of imaging techniques in administration routes other than intravenous injection, such as pulmonary and oral delivery Translational research leading to clinical applications Imaging drug delivery in large animal models Clinical applications of imaging techniques to guide drug development and drug delivery Chapters are based on a thorough review of the current literature as well as the authors' firsthand experience working with imaging techniques for the development of novel drug delivery systems. Presenting state-of-the-technology applications of imaging in preclinical and clinical evaluation of drug delivery systems, Drug Delivery Applications of Noninvasive Imaging offers cost-effective strategies to pharmaceutical researchers and students for developing drug delivery systems that accurately target a broad range of disease conditions.
This book covers various aspects of antibody mediated drug delivery systems – theoretical aspects, processing, viral and non-viral vectors, and fields where these systems find and /or are being evaluated for applications as therapeutics and diagnostic treatment. Chapters discuss actual applications of techniques used for formulation and characterization. Applications areas include cancer, pulmonary, ocular diseases; brain drug delivery; and vaccine delivery. The contributing authors represent over 10 different countries, covering recent developments happening around the globe.